What is Pellet Therapy?

This is an old (as old as Premarin) and well-documented method of delivering bioidentical hormones that utilizes small pellets about the size of a grain of rice that are painlessly inserted under the skin (the procedure is less painful than having your blood drawn).  We’ve found the easiest and best place to insert them is under the skin of the lateral buttocks.  The hormones in the pellets are bioidentical (exact molecular match of human hormone) and consist of either estradiol, the most important of the three female human estrogens, and testosterone.  Some women are surprised to hear that they might need testosterone replacement as well as estrogen replacement.  Perimenopausal women and post-menopausal women usually need some of both. Testosterone levels are usually around 5-10% that of a man.  Testosterone helps with a number of issues including libido, mood stabilization, brain function, and bone density.

Pellets are synthesized from soybeans.  They are either pure estradiol or pure testosterone.  Other than a small amount of stearic acid as is common in pharmaceuticals, there are no other ingredients in them.  They dissolve completely with no residual under the skin over a 3-6 month period.  Even though they are made from soybeans, it’s very unlikely that soy sensitive individuals would have a problem tolerating them.

The pellets are manufactured by special compounding pharmacies in the Midwest. The ingredients (estradiol or testosterone) are U.S.P. pharmaceutical grade, and our primary source states, "In our state-of-the-art Class 100 clean room, we compound sterile custom tailored prescription medications utilizing strict aseptic techniques. Our pharmacy staff has specialized training ensuring that each preparation is formulated with the strictest standards for sterility, according to Missouri State Pharmacy Board and ASHP/USP (American Society of Health-System Pharmacists/U.S. Pharmacopeia) guidelines."

Pellet therapy is used to defeat the symptoms of menopause and perimenopause.  Suzanne Somers has authored two very informative books, "The Sexy Years" and "Ageless," where she describes the symptoms of menopause as the Seven Dwarfs of Menopause – Itchy, Bitchy, Sweaty, Sleepy, Bloated, Forgetful, and All Dried Up.  These symptoms respond extremely well to subcutaneous bioidentical hormone replacement therapy.

Inserting these little pellets into the body is sort of like inserting tiny new ovaries, because they do what the ovaries used to do – slowly release hormones into the bloodstream in a manner similar to how the ovaries did.

Many women have tried various kinds of hormone replacement therapy (HRT), and have simply been dissatisfied with the way they have felt.  Others have worried about reports of increased breast cancer or heart attacks.  But because bioidentical subcutaneous hormone replacement is so different from conventional HRT, it is unlikely that negative data on conventional HRT even applies to pellet therapy.  Many patients don’t do well on any other form of HRT except subdermal bioidentical pellet therapy.